If you don't bet 5 coins per line you (almost certainly) won't get 800 per coin for a Royal Flush, but 250 per coin instead.
I won't step down in paytable just to go up in lines. I will, however, step down in denomination to flatten out the ride. No choice, really, in stepping down because 50-play 5c NSU is about the best out there.
I have found these to be about the same:
25c 1-line NSU/FPDW ($1.25/bet)
10c 10-line NSU ($5.00/bet)
5c 23-line NSU ($5.75/bet)
50-line 5c NSU is a little too wild for my comfort level, at $12.50/bet, so I play it at 23 lines.
In all of these permutations, losing $250-$300 in a modest (2-3 hour) session is about the worst you can expect, but you won't get the monster win on the multi-line games unless you're dealt deuces or a royal. But dealt flushes and higher happens fairly frequently and are a nice cash boost. Dealt wild royals and 5OAK happen too.
Good way for a quarter player to get coin in per hour up while reducing the risk of a really big hit to the bankroll (or a really short session).
Edited by Quad Deuces - 16 May 2012 at 3:08am